Balgarianovinite.com A team of scientists from the Centre for Plant Systems Biology and Biotechnology (CPSBB) and the Metabolomics Laboratory at the Bulgarian Academy of Sciences (BAS) has secured utility model protection for a newly developed combination of natural bioactive compounds – maackiain, betulinic acid, and piperine, the CPSBB said on Thursday. The development is the result of the team’s research into natural compounds with potential to support metabolic health and processes associated with healthy aging.
The compounds were obtained after a five-year study through preclinical experiments using the model organism C. elegans. Extensive studies in rodents found no toxic effects under the conditions and doses tested. A clinical study involving humans is planned to validate the findings based on indicators associated with metabolic processes in the human body.
Metabolic disorders and obesity are among the most serious global health challenges.
According to the World Health Organization (WHO), approximately 2.5 billion adults worldwide were overweight in 2022, while one in eight people globally was living with obesity. The prevalence of obesity has more than doubled since 1990, and analyses indicate that the trend continues to increase worldwide. The latest World Obesity Atlas 2025, an international analytical report on global trends in overweight and obesity, projects that the number of adults living with obesity will reach approximately 1.13 billion by 2030 – an increase of more than 115% compared with 2010, when the figure stood at around 524 million. The WHO also notes that approximately 35 million children under the age of five were overweight in 2024.
In this context, scientists from the CPSBB and BAS are directing their research efforts toward natural compounds that may influence these complex molecular processes, with the combination of the newly identified substances designed to produce a synergistic effect on metabolic regulation.
The researchers’ main goal is the pilot market transfer of the combination in the form of a dietary supplement, followed in the longer term by the development of a medicinal product. The dietary supplement will contain standardized plant extracts based on the newly identified combination and will be intended to provide general support for metabolic processes in the human body. Production is expected to be carried out in partnership with a Bulgarian company with an established background in the dietary supplement market.
“Modern science shows that complex health conditions such as metabolic disorders require a multidisciplinary approach. Our goal is not to talk about miracle solutions, but to develop scientifically grounded approaches that go through all the necessary stages — from the laboratory to real-world application. For Bulgaria, such transfers of research developments to the market are an important step toward building an ecosystem for innovation with genuine social impact,” the head of the research team, Prof. Milen Georgiev, said.
“Partnerships between scientific organizations and industry create an opportunity for Bulgaria to develop a market in the science-based products segment,” Georgi Filipov added, manager of Fortex Nutraceuticals, a Bulgarian company specializing in the production of dietary supplements, with markets in Bulgaria and nearly 30 countries worldwide. Bulgarian Scientists Develop Novel Bioactive Combination for Metabolic Health 2026 THE NEWS FROM BULGARIA – NEWS AGENCY 2009-2025 2026-08-20 14:36:15 Latest news World news Country news Most important news latest news most important latest of the day Justice Petar Nizamov Feathers Petar Nizamov- Feathers Justice bg iustitia.bg iustitia iusticia usticia investigation Burgas Bulgaria news news of the last hour news of the day news of today Bulgaria news The news from Bulgaria blitz news top news most important most commented latest news Boyko Borisov news weather coronavirus news news weather facebook youtube facebook instagram news today news of the last minutes news today today news news bg news leading news hot news bg news site for news all news news bg news of the last hour latest latest news bg news of today news today news today news of the last hour latest news today news bg news news 24 hours news vesti bg novini news world bird bg bivol bg bivol trud bg novini latest news today novinite bg news hello bulgaria political party coat of arms delyan peevski scandalous Bulgarian National Television Free Europe Television scandal exclusive live tv live right now tv tv online tv program bg live now tv news online tv online live court Burgas court Burgas district court Burgas court Burgas district court Burgas district court Burgas appellate court Burgas prosecutor Burgas prosecutor’s office Burgas district prosecutor’s office Burgas district prosecutor’s office Burgas district prosecutor’s office Burgas district prosecutor’s office Burgas district prosecutor’s office Burgas district prosecutor’s office Prosecutor General Ivan Geshev Prosecutor Geshev Tsatsarov Ministry of Internal Affairs Burgas ODMR Burgas ODPR Burgas police Burgas district police Burgas prosecutor Tsatsarov SGS cases Varna court chairman of the SGS court decisions on civil cases decisions on cases Plovdiv court decision of the court decisions cases Varna court criminal cases district district court decisions work in the court SGS chairman of the SGS judges Sofia court post judges Plovdiv court Plovdiv judges Plovdiv Supreme Court Inspectorate Supreme Court Supreme Judicial Council lawyer lawyer criminal cases lawyer civil cases lawyer marriage cases lawyer administrative criminal law criminal process civil law civil process administrative law constitutional law